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L Liotta, M Ferrari, and E Petricoin (2003)

Clinical proteomics: Written in blood

Nature 425:905.

The blood contains a treasure trove of previously unstudied biomarkers that could reflect the ongoing physiologic state of all tissues. Every cell in the body leaves a record of its physiological state in the products it sheds to the blood, either as waste or as signals to neighbouring cells. What some may view as a cellular refuse is really a diagnostic gold mine.